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What is the in vitro fertilization (IVF)

Actually infertility has come to be defined as the inability to conceive after 12 months of regular unprotected sexual intercourse. Correct understanding etiology of sterility provides quick and effective individualized treatment. Generally infertility can be caused by man’s or woman’s health problems, and sometimes – by both-side disorders when both the man and the woman have abnormalities which make a conception impossible. No doubt time is considered a crucial moment in reproductive area thus depending on woman’s age after 6-12 months of ineffective planning for pregnancy it is necessary to consult fertility specialists in order to assess personal risks and initiate proper examination.

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In vitro fertilization

According to the World Health Organization data about 50 million couples all over the world have faced infertility. It can be primary – if a woman has never been pregnant – and secondary – when a pregnancy has already taken place.

The probable causes of infertility are the following:

Male factor:

  • Abnormal sperm production or function
  • Problems with the delivery of sperm due to sexual problems (premature/delayed ejaculation), genetic diseases or structural problems
  • Exposure of certain environmental factors such as radiation, chemicals, taking select medications (anabolic steroids, antihypertensives), etc.
  • Damage associated with cancer and its treatment

Female infertility factors:

  • Hormonal disorders which contribute chronic anovulation
  • Uterine or cervical abnormalities
  • Fallopian tube blockage often related to pelvis inflammatory disease resulted from endometriosis, sexually transmitted infections and adhesions
  • Endometriosis – when endometrial cells that make up the uterine lining start growing outside the uterus. It affects normal functioning of ovaries, tubes and uterus resulting in pain syndrome and infertility
  • Primary ovarian insufficiency (early menopause) when the ovaries stop working properly and menstruation ends before the age of 40
  • Cancer and its treatment
  • Idiopathic infertility, when there are no obvious disorders found out during the couple examination

Up to date the in vitro fertilization is considered to be safe and the most effective method of infertility treatment.

In vitro fertilization (IVF) is

In Vitro Fertilization is an assisted reproductive technology (ART) commonly referred to as IVF. IVF is the process of fertilization by egg pick-up, retrieving a sperm sample, and then manually combining an egg and sperm in a laboratory dish in conditions close to natural ones. Once the embryo is obtained is ready to be transferred into the uterus.

Generally there are five basic steps in assisted reproductive technology program:

01
Step 1

With the aim to provoke multiple growth of follicles and production hormonal treatment is prescribed. The very medications are selective and safe thus providing very delicate effect. This stage lasts about 2 weeks and requires 2-4 control visit to clinic. A transvaginal ultrasound is used to monitor the ovaries, and blood test samples are taken to check hormone levels.

02
Step 2

Ovum retrieval is considered to be a minor surgical procedure with ultrasound imaging guidance. It’s usually performed under intravenous anesthesia to avoid any possible discomfort.

03
Step 3

The man is asked to produce a sample of sperm, which is prepared for following fertilization

04
Step 4

In a process called insemination, the sperm and eggs are mixed together and stored in a laboratory dish to encourage fertilization. The eggs are observed to confirm that fertilization and cell division go properly. Once this occurs, the fertilized eggs are considered embryos. Thus the stage of embryo cultivation is started. This period lasts 5-6 days till the embryos reach the stage of blastocyst and are ready to be transferred into uterus of patient or surrogate mother.

05
Step 5

When performing transfer a special catheter is inserted into the uterus to deliver the embryos. This procedure is painless in majority of cases, although some women may experience slight discomfort.

“AVA-PETER” clinic was one of the first clinics which has used so-called the elective single-embryo transfer technology – eSET – an approved tool to minimize risk of multiple pregnancy

Elective single-embryo transfer technology

ICSI

ICSI (intracytoplasmic sperm injection) is one of the assisted reproductive technologies (ART) methods, used in cases of severe male factor (semen absence/deficiency, low motility or bad quality of spermatozoa). Through this procedure, a single sperm is injected directly into the oocyte in an attempt to achieve fertilization. Nowadays just a small amount of normal spermatozoa is needed to achieve good results after ICSI.

The MSOME-IMSI

The MSOME-IMSI (motile sperm organelle morphology examination - intracytoplasmic morphologically selected sperm injection) is an actual method which allows to assess morphological features of native spermatozoa. The semen image is enlarged in 6300 times with the use of a new electrooptical microscope. This method is used also in cases of severe male infertility and helps the doctor to make a decision, which method would be the most effective one for infertility treatment: the IVF, ICSI or IMSI. This technology facilitates better IVF outcomes, lower risk of miscarriage and fetal abnormalities. Each infertility case is unique and requires individual approach. The treatment plan is to be identified only after entire examination of the couple and diagnosis verification. The effectiveness of IVF depends on numerous factors including the infertility period and the woman’s age. According to the long-term experience of using this method, it is evident that children born with the IVF do not have any increased potential risks to their health.

Each infertility case is unique and requires individual approach. The treatment plan is to be identified only after entire examination of the couple and diagnosis verification. The effectiveness of IVF depends on numerous factors including the infertility period and the woman’s age. According to the long-term experience of using this method, it is evident that children born with the IVF do not have any increased potential risks to their health.

You can make an appointment with the fertility specialist of the “AVA-PETER” clinic in Saint-Petersburg, and ask for further information: +7 (812) 600-77-78.

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